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This is a great summary of the discovery of Green Fluorescent Protein and its application in genetics and protein tracking, eventually leading to the creation of GFP-carrying Axolotls, Ambystoma mexicanum, in 2006.
Excerpt from this article:
"What makes a jellyfish glow? For scientists, asking that simple question led to a powerful new tool that’s completely transformed medicine — and won the Nobel!
In 2007, researchers at UC San Diego watched breast cancer cells migrate in real time. In 2009, scientists at UC Davis and Mount Sinai School of Medicine captured video of HIV spreading between immune cells. Biological processes that were once hidden from us can now be lit up like a firefly, and it’s all possible thanks to an experiment that was tossed down the drain."
Read the rest here:
www.universityofcalifornia.edu
And here is a link to the (free) paper describing the creation of GFP Axolotls:
www.sciencedirect.com
Excerpt from this article:
"What makes a jellyfish glow? For scientists, asking that simple question led to a powerful new tool that’s completely transformed medicine — and won the Nobel!
In 2007, researchers at UC San Diego watched breast cancer cells migrate in real time. In 2009, scientists at UC Davis and Mount Sinai School of Medicine captured video of HIV spreading between immune cells. Biological processes that were once hidden from us can now be lit up like a firefly, and it’s all possible thanks to an experiment that was tossed down the drain."
Read the rest here:
How basic research on jellyfish led to an unexpected scientific revolution
From destined for the drain to winning a Nobel Prize.
And here is a link to the (free) paper describing the creation of GFP Axolotls:
A germline GFP transgenic axolotl and its use to track cell fate: Dual origin of the fin mesenchyme during development and the fate of blood cells during regeneration
The development of transgenesis in axolotls is crucial for studying development and regeneration as it would allow for long-term cell fate tracing as …
www.sciencedirect.com