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Old 19th August 2008   #1
Coen Deurloo
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Default CA Press: A Blueprint to Regenerate Limbs

Probing the salamander genome reveals clues to its remarkable ability to regrow damaged limbs and organs.

In its own way, the axolotl salamander is a mighty beast. Chop off its leg, and the gilled creature will grow a new one. Freeze part of its heart, and the organ will form anew. Carve out half of its brain, and six months later, another half will have sprouted in its place. "You can do anything to it except kill it, and it will regenerate," says Gerald Pao, a postdoctoral researcher at the Salk Institute for Biological Studies, in La Jolla, CA.

That extraordinary power of regeneration inspired Pao to probe the axolotl salamander's DNA. Despite decades of research on the salamander, little is known about its genome. That began to change last year, when Pao and his collaborators won one billion bases' worth of free sequencing from Roche Applied Science, based in Indianapolis. Now that the data is in, scientists can finally begin the hunt for the genetic program that endows the animal with its unique capabilities.

http://www.technologyreview.com/Biotech/21265/page1
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