I've had Plecos in my tank (they were there before I had Axolotls) And well before there was so much knowledge available. I also had crayfish. But I also kept my tank well stocked with feeders, and fed my Axie's earthworms. The crayfish will defend themselves, so one of my boys got a pincher on the snout, but they never touched the Plecos.
I threw in some other types of decorative fish once, but they were just meals in waiting.
I would just keep a sponge on a stick handy to wipe down the insides on the tank every few days.